PCAF is also associated with multiple hepatic metabolic and pathogenic diseases, such as metabolic syndrome, inflammation, apoptosis, injury, and cancer, via the acetylation of non-histone proteins such as phosphoglycerate kinase 1 (PGK1), ATP-citrate lyase (ACLY), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1-α), forkhead box P3 (FOXP3), and p53 [32]. This evidence concerns the gene TP53 and metabolic syndrome.