NLRP3 and neuropathic pain: In this regard, it has been demonstrated that activation of microglial NMDARs triggers inflammation and neuronal cell death [20] and activates the NLRP3 inflammasome pathway [21], while P2X7Rs in turn give rise to noncanonical activation of the NLRP3 inflammasome, which has been linked to the pathogenesis of neuropathic pain, among other conditions [22].