VEGFA and diabetes mellitus: It was demonstrated that elevated levels of glucose, mimicking the glucose levels found in people with diabetes, induce apoptosis of HUVECs; slow down proliferation; disrupt the cell cycle; induce DNA damage; decrease production of interleukin 8 (IL-8); increase the expression of inflammatory cytokine interleukin 6 (IL-6); decrease vascular endothelial growth factor (VEGF) levels; and decrease angiogenesis [23,24,25,26,27,28,29].