CA-rich extracts from Echinacea purpurea have been demonstrated to exhibit cytotoxic effects via activating caspase -3/-7 mediated apoptotic pathway in a time- and dose-dependent manner on MIA PaCa-2 (IC50:62.92 ± 2.24 μg/mL) and COLO320 (IC50: 25.36 ± 1.14 μg/mL) human cancer lines [35]. Here, CASP3 is linked to cancer.