Furthermore, the regulatory trend of nonclassical Gln metabolism is consistent with the malignant behavior of KrasG12D-LOH pancreatic cancer cells, suggesting that KrasG12D-LOH may regulate the malignant phenotype of pancreatic cancer through HIF-2α/c-Myc-mediated Gln metabolism. The gene discussed is EPAS1; the disease is pancreatic neoplasm.