DAG1 and congenital muscular dystrophy due to LMNA mutation: It has been shown that hypoglycosylation of α-dystroglycan is revealed by loss of VIA4-1 antibody immunoreactivity, and mutations in congenital muscular dystrophies-causing glycosyltransferases lead to the hypoglycosylation and reduced laminin-binding activity [2,31,32,33].