Interestingly, we encountered a case of IgE-allergic AD with lichenified eczema, in which co-expression of HDM antigens was observed only with IgE+ LCs in the areas around spongiotic vesicles and not with IgE+ IDECs in the central area of the lesion (Figure 3k,l), similar to the preceding case of a patient with a spongiotic vesicle in the APT-positive reaction site [86]. Here, IGHE is linked to Eczematoid dermatitis.