Therefore, it is speculated that the spongiotic dermatitis observed in eczematous dermatitis of patients with non–IgE-allergic AD might be caused by haptens and allergens (e.g., metals and HDMs) that induce standard (IgE-independent) delayed-type hypersensitivity or an immune response similar to systemic-type contact dermatitis [60]. This evidence concerns the gene IGHE and spongiotic dermatitis.