Furthermore, in our histopathological analysis, approximately 60% of the examined cases of IgE-allergic AD with HDM allergy exhibited accumulation of IgE+ IDECs that captured HDM antigens in the central areas of the spongiosis lesions (approximately 8 on average per 0.24 mm2 in a 200× visual field) (Figure 3i) [76]. Here, IGHE is linked to allergic disease.