NR3C2 and obesity due to melanocortin 4 receptor deficiency: Indeed, several studies using tissue-specific MR knockout mouse models have shown that the MR in various cell types, including smooth muscle cells, endothelial cells, and myeloid cells, contributes to the development of various kidney disorders, such as ischemic reperfusion- [14], cyclophosphamide- [15], and obesity-mediated kidney fibrosis [16], as well as glomerulonephritis [17].