TRPM8 and neoplasm: In accordance with bioluminescence measurements, we found that TRPM8 overexpression decreased the tumor weight by 42.89 ± 7.73% in PC3–M8 luc cl5 grafts (175.08 ± 23.90 mg for PC3–M8 luc cl5 tumors versus 348.6 ± 48.52 mg for PC3 luc tumors) and by 66.31 ± 5.79% in PC3–M8 luc cl2 grafts (95.83 ± 6.99 mg for PC3–M8 luc cl2 tumors versus 348.6 ± 49.52 mg for PC3 luc tumors) (Figure 1C).