The comparison of the tumor area between PC3 luc and PC3–M8 luc grafts also confirmed the inhibitory role of TRPM8 in PCa growth, showing a reduction in the tumor area of 79.91 ± 3.28% in PC3–M8 luc cl5 and 64.24 ± 3.41% in PC3–M8 luc cl2 (Figure 1D). This evidence concerns the gene TRPM8 and posterior cortical atrophy.