TRPM8 and posterior cortical atrophy: TRPM8 overexpression by itself inhibits PCa cell migration, and TRPM8 activation by endogenous and exogenous agonists, such as prostate–specific antigen (PSA), icilin, menthol, and WS12, further enhances the inhibitory effect of metastatic PCa cell motility [13,14,17,21].