More precisely, the overexpression of TRPM8 induced a significant decrease in PCa growth, which was already evident 4 weeks after the orthotopic graft and was equal to 93.34 ± 1.81% in PC3–M8 luc cl5 and 98.04 ± 0.48% in PC3–M8 luc cl2 5 weeks later (Figure 1A,B). Here, TRPM8 is linked to posterior cortical atrophy.