More specifically, TRPM8 was found to be essential for cell survival and proliferation in PCa cells sensitive to androgens, such as LNCaP cells, in vitro [16,20,29], whereas it displayed an anti–proliferative and pro–apoptotic effect on androgen–insensitive PCa cells, such as PC3 and DU–145 cells [13,14,15]. This evidence concerns the gene TRPM8 and posterior cortical atrophy.