Orai1-store-operated Ca2+ entry (SOCE) intracellular Ca2+ oscillation upregulation can activate downstream pathways, stimulate the proliferation and migration of esophageal squamous cell carcinoma (ESCC) cells, enhance their ability to invade other tissues, and promote the formation and growth of ESCC tumors in vitro and in vivo [26]. The gene discussed is ORAI1; the disease is esophageal squamous cell carcinoma.