EVA1A siRNA partially inhibited flubendazole-induced DRP1 expression, decreased the expression of PINK1, Parkin and p-Parkinser65, and alleviated the decrease in mitochondrial membrane potential and ATP loss induced by flubendazole in MDA-MB-231 and MCF-7 cells, suggesting that flubendazole promotes DRP1-mediated mitophagy and mitochondrial dysfunction in breast cancer by upregulating EVA1A. The gene discussed is EVA1A; the disease is breast cancer.