There are ongoing trials of CAR-T cells in HCC, such as a phase I–II study (NCT03013712) that assesses EpCAM-CAR-T targeting EpCAM, aphase I study (NCT03198546) of GPC3/TGFβ-CAR-T targeting GPC3 and TGFβ in HCC, as well as a phase I study (NCT03884751) of CAR-GPC3 T Cells targeting GPC3 in HCC. Here, EPCAM is linked to hepatocellular carcinoma.