Cancer-associated inherited syndromes leading to the minority of GC cases include Catenin Alpha 1 (CTNNA1) gene mutation and Cadherin 1 (CDH1) gene, as well as Glutathione S-Transferase Mu 1 (GSTM1)-null mutation, found in Diffuse Gastric Cancer (HDGC) and Lynch syndrome respectively, while there are also notable epigenetic modifications that promote gastric carcinogenesis [78]. This evidence concerns the gene GSTM1 and cancer.