HMGB1 and liver disorder: A plethora of signals can cause matrix and cellular alterations and, therefore, determine the initiation and progression of liver disorders, such as the following: the release of PAMPs (e.g., LPS, lipoteichoic acid (LTA), and β-glucan; the release of DAMPs by damaged/dead hepatocytes (e.g., high mobility group box 1 (HMGB1), mitochondrial DNA (mtDNA), and ATP); the release of reactive oxygen species (ROS) by damaged/dead hepatocytes; an hypoxic environment (e.g., due to the enhanced expression of hypoxia-inducible factor (HIF)-1α) [56].