Their diet often has a higher intake of saturated fatty acids, noncomplex sugars, red meat, and alcohol, which further exacerbate psoriasis and its comorbidities by activating the inflammasome cascade, tumor necrosis factor-α (TNF-α)–interleukin (IL) 23–IL-17 axis, generation of reactive oxygen species, intestinal dysbiosis, and suppression of regulatory T cells [43];. This evidence concerns the gene TNF and psoriasis.