In EBV-positive gastric cancer, deregulated activation of PAR1b by EBV-encoded RNAs such as EBERs may underscore neoplastic transformation of cells as opposed to the case of intestinal-type (CIN type) gastric cancer in which H. pylori CagA-induced inactivation of PAR1b and subsequent induction of BRCAness is critically involved in the development of cancer. Here, MARK2 is linked to cancer.