In the case of NANOS3 overexpression, 14 infertility related genes (BUB1B, CCNB1, SALL4, POU5F1, TRIM32, CDC20, CFTR, TGFB3, DHCR7, SIRT1, HSPA2, ADAMTS5, BMR1A, and WNT6) and 10 cancer-germ cell genes (NEK2, CENPA, CENPL, KIF18A, ASPM, CENPE, FBXO10, KIF9, MED26, and SLCO4C1) were present in 8 clusters (Figure 2C and Figure S4). Here, SIRT1 is linked to cancer.