P2RX7 and myeloid sarcoma: Applying sequencing analysis of P2X4 receptor and P2X7 receptor in 193 MS patients and 100 controls, Sadovnick et al. were able to identify a three-variant haplotype (P2X7 receptor rs140915863:C > T (p.T205M), P2X7 receptor rs201921967:A > G (p.N361S) and P2X4 receptor rs765866317:G > A (p.G135S)) separating with disease in a multi-incident family with MS.