In order to study the association between granzyme secretion and degranulation activity, we divided the COVID-19 patients according to low and high degranulation levels and observed that there was a correlation between those patients with impaired degranulation activity and a significant reduction in the secretion of granzyme A: 3900.4 pg/mL (2768.5–10,040.2) vs. 13887.2 (7,986.5–27,507.6), p = 0.018 (Figure S5C). Here, GZMA is linked to COVID-19.