Finally, sirtuin-1, zonula occludens-1, urokinase plasminogen activator surface receptor (uPAR) and SRY (sex determining region Y)-box 2 (SOX2) were also downregulated by ONC in A375 melanoma cells [147], in line with the low invasiveness and low metastatic potential effects previously found [109]. Here, SOX2 is linked to melanoma.