In mesothelioma cells, ONC downregulates the expression of NF-κB and of its target genes, such as the ABC transporter, the apoptosis regulator Bcl extra-large (Bcl-xl), the inhibitor of apoptosis (cIAP) and the metalloproteinase-9 [143,144]. The gene discussed is NFKB1; the disease is mesothelioma.