To determine whether CXCL1 and/or CXCL2 promoted neutrophil recruitment in E.-coli-K1-induced meningitis, mice were subjected to intracranial co-injection of E. coli K1 with a blocking antibody against CXCL1 or CXCL2, and neutrophil recruitment was analyzed using FACS. This evidence concerns the gene CXCL1 and meningitis.