PTH and diabetes mellitus: This blunting effect of diabetes on PTH is also reflected by our data showing miRNA dysregulation induced by PTH treatment in the ulna bones of WT rats but not in the bones of ZDF rats (Supplementary Figure S5C,D), which also supports the concept that the partial mediation of the PTH anabolic effects on the bones of WT rats could be through the regulation of bone miRNAs.