Prominent genes were RHOA, AKT1, RAC1, MDM2, CDKN1A, and VEGFA, which play important roles in TGF-beta and mTOR signaling (KEGG database), signaling by Wnt and by NOTCH (Reactome database), and in complications in diabetes mellitus (DisGeNET database). This evidence concerns the gene RAC1 and diabetes mellitus.