PTPN11 and neuroblastoma: Preclinical NB studies have demonstrated that pharmacological inhibition of SHP2 with SHP099, RMC-4550, and II-B08 in combination with trametinib, vemurafenib, and ulixertinib inhibitors suppresses the growth and the downstream RAS/MAPK signaling in NB cells in vitro and in vivo [48].