MKI67 and colorectal carcinoma: Conversely, downregulation of FASN expression in FASN+/∆/Apc/Cre and FASN∆/∆/Apc/Cre is associated with a decrease in the percentage of Ki67 positive cells and the intensity of Ki67 staining, suggesting that high expression of FASN is associated with a higher proliferative activity of CRC cells.