A study, focused on defining the difference between AD and Pso expression of genes, found that TRP vanilloid 2, TRP ankyrin 1, protease-activated receptor 2 (PAR2), protease-activated receptor 4 (PAR4), and IL-10 were increased only in atopic skin, while the expression of genes for TRP melastatin 8, TRP vanilloid 3, phospholipase C, and IL-36α/γ were elevated only in pruritic-psoriatic skin [42]. Here, F2RL3 is linked to Alzheimer disease.