Other studies found correlations between the serum IL-31 level and the serum IgE, eosinophil cationic protein (ECP), disease severity, and subject-itch intensity to certain degrees in AD patients [4,21,22], even though this was not confirmed by other publications, which found that IL-31 levels do not relate to disease severity [23,24]. The gene discussed is IGHE; the disease is Alzheimer disease.