IGHE and food allergy: We used the Balb/cJ mouse to generate the hyper-IgE plasma used in this study because: (i) this strain of mouse is genetically prone to develop food allergies; (ii) allergic responses to several food proteins in this mouse strain are similar to humans with food allergies to hazelnut, cashew nut, sesame, shellfish and wheat gliadins and non-gluten allergens including lipid transfer protein [28,40,45,46,47,48,49]; and (iii) we have extensively characterized the allergic response to salt-soluble wheat proteins in this model previously [40,42,44].