INSR and type 1 diabetes mellitus: IAs were significantly less frequent in patients with T1D carrying one or two copies of rs2245649(C) and rs2229429(A) in INSR (OR = 0.28, p = 0.008 and OR = 0.30, p = 0.002, respectively) than in patients homozygous for the major alleles of these SNPs, after correction for age and sex (Table 4).