While we found no association between SNPs in INS and glycaemic control (data not shown), we observed an overall allele dosage effect of both rs2245649 (p = 0.04) and rs2229429 (p = 0.006) in INSR on HbA1c levels (Figure 1A,B, respectively), the latter being seemingly driven by T1D for rs2229429 (p = 0.04, Figure 1B). This evidence concerns the gene INSR and type 1 diabetes mellitus.