MME and Alzheimer disease: Furthermore, in the Alzheimer’s disease (AD) model, neutral endopeptidase (NEP), which is the enzyme responsible for the rate-determining process of amyloid-beta (Aβ) in the brain of patients with this disorder and excessive accumulation of Aβ is one of the major characteristics of the pathophysiology of AD, was higher in adipose-derived MSCs than in bone-marrow-derived MSCs and contributed to the higher efficiency of Aβ degradation [230,231,232].