Tumors with a high RvD score evidenced increased CD4+ and CD8+ T cell infiltration, key for anti-tumor immunity in HNSC [39,40], but also decreased levels of anti-tumoral effectors such as plasma and dendritic cells, even if a specific subpopulation of these cells may also have a pro-tumorigenic role [41]. The gene discussed is CD4; the disease is neoplasm.