In addition, to evaluate if RvD scores are also correlated with immune activation, levels of end-products of anti-tumor immunity such as granzymes A and B (GZMA and GZMB, respectively), perforin (PRF1) and the cytolytic score [20,33] were evaluated in HNSC patients as surrogate markers of CD8+ T cell tumor cytotoxicity. Here, PRF1 is linked to neoplasm.