In addition, the Ingenuity Pathway Analysis (IPA) software revealed that genes modulated in the RvD high score group were associated with major biological themes related to anti-tumor immunity, such as Th1 pathway, and leukocyte activation and cytotoxicity, mainly driven by activation of interleukin-1β (IL1B), tumor necrosis factor α (TNF) and interferon γ (INFG) (Figure 3C). Here, TNF is linked to neoplasm.