In particular, a population of p-EMT tumor cells was labeled with high expressions of SPRR1B (Small Proline Rich Protein 1B, a cross-linked envelope protein of keratinocytes), a prognostically predictive biomarker for lung adenocarcinoma, overexpressed in human OSCC stem-like cells relating to cell growth through the activation of MAP kinase signals [29,30]. The gene discussed is SPRR1B; the disease is neoplasm.