A very recent paper by Mossakowska et al. compared functioning corticotropinomas and SCAs (28 vs. 20 cases, respectively); while the authors did not find any differences in patients’ age at presentation, tumor invasiveness, proliferation index, and proportions of sparsely and densely granulated adenomas, they observed instead a higher expression of miR-124-3p in ACTH-secreting tumors, leading to GR downregulations, which in turn reduces the effect of GR feedback on corticotroph adenoma [67]. This evidence concerns the gene NR3C1 and ACTH-producing pituitary gland adenoma.