Wang et al. [72] noted that this flavonoid could inhibit the apoptosis of NP cells and ECM degeneration induced by oxidative stress via the sirtuin 1 (SIRT1)-autophagy pathway in vitro, while in-vivo studies demonstrated that quercetin could alleviate IDD progression in rats. This evidence concerns the gene SIRT1 and intervertebral disk degenerative disorder.