Additionally, Wang et al. [38] suggested that E2 could inhibit NP cell apoptosis by suppressing the NF-κB signal pathway, being a promising mechanism for preventing the occurrence or progression of IDD, both in vitro (i.e., human NP cells collected from women) and in vivo (i.e., rat coccygeal IDD model). Here, NFKB1 is linked to intervertebral disk degenerative disorder.