These cells produced the desired exosomes in situ, which further penetrated the annulus fibrosus and transported Sphk2 into the NP cells, where Sphk2 activated the (PI3K)/p-AKT pathway and the intracellular autophagy of NP cells, eventually resulting in the amelioration of IDD. The gene discussed is SPHK2; the disease is intervertebral disk degenerative disorder.