In this process, profound, simultaneous effects on lipophagy, mitophagy, lipogenesis, lipid oxidation, redox balance, cholesterol turnover, gluconeogenesis, pancreatic insulin secretion, peripheral insulin resistance [57,58], fibrogenesis [59], and inflammation [60] have been reported, providing a range of effects on cellular and systemic homeostasis that can comprise protective or detrimental responses during aging. Here, INS is linked to Insulin resistance.