LGI1 and encephalitis: In addition to mutations in the LGI1 gene causing rare autosomal dominant lateral temporal lobe epilepsy (ADLTE) [111], LGI1 encephalitis, which usually occurs in men older than 60 years of age [112,113,114], is characterized by repetitive, brief faciobrachial dystonic seizures (FBDSs) [112], as well as behavioral changes and disorientation.