MAPT and early-onset autosomal dominant Alzheimer disease: Widespread dysregulated protein phosphorylation, in addition to tau hyper-phosphorylation, via extensive kinase activation occurs in Alzheimer’s disease (AD), thus contributing to abnormal function of cell membranes, cytoskeleton, synapses, neurotransmitter receptors, energy metabolism, RNA processing and splicing, protein synthesis, and cell signaling [9,10,11,12,13].