Nevertheless, studies that identified melanocortin-independent processes observed relative weight differences between treatment groups (e.g., activity-based anorexia [59,60], AgRP neuron ablation-induced anorexia [61], xenin-induced anorexia [62], histamine-induced anorexia [63], and cannabinoid-induced anorexia [64]). This evidence concerns the gene AGRP and Anorexia.