A recent Chinese study reported the preparation of eight 2, 4-disubstituted-5-(trifluoromethyl) pyrimidine compounds (formula not disclosed) able to block FAK at nanomolar levels (IC50 = 6 nM) and to inhibit proliferation of different cancer cell lines (U87-MG and A549) at micromolar concentration [42]. The gene discussed is PTK2; the disease is cancer.