Some of these new Sul-DPPYs evidenced good activity against FAK (IC50 values lower than 100 nM) and compound 1 (Figure 2, IC50 = 86.7 nM) was able to block, in the low micromolar range, the proliferation of several classes of refractory cancer cell lines, including the PC cell lines (AsPC-1, Panc-1 and BxPC-3), NSCLC-resistant H1975 cell line, and the B lymphocyte cell line (Ramos cells). Here, PTK2 is linked to pachyonychia congenita.