F2R and carotid atherosclerosis: Interestingly, recent immunofluorescence experiments revealed colocalization of PAR1 with toll-like receptors (TLRs)—TLR2 and TLR4—in human carotid atherosclerotic lesions, pointing to activation of TLRs and interaction with PAR1 in an innate immune response in carotid atherosclerosis [7].