To evaluate possible alterations in the function of the epithelial barrier around implants that may be related to the occurrence of peri-implantitis, the gene expression of factors associated with the differentiation of Th cells in the Th22 subpopulation (AhR, IL-22, and IL-6) were evaluated in peri-implant soft tissues. This evidence concerns the gene IL6 and Peri-Implantitis.