The primary objectives of this study were to (1) examine the correlational associations between inflammatory cytokines (Interleukin 6 (IL-6) and C-Reactive Protein (CRP)) and apathy and (2) explore the direct and indirect relationships of apathy and motoric cognitive outcomes (gait velocity, slow gait, and MCR) as it relates to important cognitive risk factors including dysphoria and multimorbidity in a healthy community dwelling cohort of older adults. This evidence concerns the gene CRP and dysphoria.