MAPT and Alzheimer disease: However, besides formation of Aβ and Tau, AD development involves different cellular processes, such as the endoplasmic reticulum stress [9,10], oxidative stress that underlies neurotoxicity related neuronal loss [11], neuroinflammation [12,13], impaired glucose metabolism related to insulin/insulin-like growth factors resistance [14,15], and glial function [16,17].