The increase in the transcriptional activity of the endothelin-1 gene in the group of men, smokers, and people with lipid metabolism disorders, and among patients after myocardial infarction with ST-segment elevation (STEMI), as well as endothelin-1 receptor type A (ENDRA) with the age of the respondents may indicate another pathomechanism of pro-atherogenic activity of the above-mentioned factors. Here, EDN1 is linked to Disorder of lipid metabolism.