However, Meneses-Echávez et al. [55] conducted a meta-analysis evaluating the influence of overall exercise training on mediators of inflammation in breast cancer survivors, and only observed improvement in the concentrations of IL-6, TNF- α, IL-8, and IL-2, without any differences in the concentrations of CRP when compared to a control group who received no intervention. This evidence concerns the gene IL2 and breast carcinoma.