However, the earlier ECDC guidelines and the UK Health Security Agency define a confirmed case of acute non HepA-E hepatitis based on the presentation of acute hepatitis with elevated level(s) of transaminases (alanine aminotransferase (ALT) or aspartate aminotransferase (AST)) higher than 500 international units (IU)/L in children aged 10 years or less any time from 1 January 2022 [4]. The gene discussed is GPT; the disease is Acute hepatitis.