Some authors such as Amboni et al. compared the progression of cognitive impairment in 26 Parkinsonian patients with FoG (FoG+) and without FoG (FoG-) over a follow-up period of 2 years, finding that FoG+ patients had a faster progression of cognitive impairment, while in FoG- patients, cognitive alteration remained unchanged during this period [26]. This evidence concerns the gene ZFPM1 and Cognitive impairment.