We also found that the frequency of the missense mutation p.S229N of HLA-DQB1 gene in ASD patients (15/72 = 20.83%) was significantly higher than that in healthy controls (4/107 = 3.73%); it is well known that HLA-DQB1 is a susceptibility gene for celiac disease [74]. The gene discussed is HLA-DQB1; the disease is celiac disease.