Among the 10 recurrently found gBRCA1/2-PV (in more than 10 families) in the Japanese Organization Of Hereditary Breast and Ovarian Cancer (JOHBOC) registry in Japan [16,25], only three variants, BRCA1:c.2800C>T, BRCA2:c.6952C>T, and BRCA2:c.9076C>T, were identified in our OC cases. The gene discussed is BRCA1; the disease is ovarian carcinoma.