HNF1A and brain ischemia: The functional role of the HNF1A-AS1 rs7953249 polymorphism, located in the 5′ HNF1A gene region, and its effects on HNF1A expression are still unknow, but there have been reports of an association of rs7953249 SNP with ischemic brain injury, with the G allele demonstrating a protective effect against small vessel disease, a subtype of brain ischemia [62].