COL11A1 and open-angle glaucoma: Of the nine linked nsSNPs identified, two (rs3753841 and rs2274224) candidate variants were perfectly linked (LD r2 = 1) to POAG lead gSNPs, and rs3753841 mapping to COL11A1 gene was predicted to be ‘deleterious’ and ‘possibly damaging’ by SIFT [27] and Polyphen [29], respectively.