BICC1 and glaucoma: Moreover, our 3xSMR analysis, which was used for linking glaucoma-associated gene expression to glaucoma-associated methylation levels, enabled us to find two methylation sites (cg05938607 and cg12342675) at the BICC1 gene, confirming its likely causal role in methylation mediated genetic regulation in glaucoma (DNA→methylation→expression→glaucoma; Figure 2).