Among these, five genes (FBXO32, PLCE1, ARHGEF12, LPP, and BICC1; p ≤ 8.75 × 10−7, FDR < 0.01) showed higher evidence of functional involvement in POAG pathogenesis (Supplementary Table S2A). The gene discussed is BICC1; the disease is open-angle glaucoma.