Cardiovascular-related terms, e.g., abnormal aorta morphology from the MP pathway resource, and Wnt and TGF-β signaling terms from the KE pathway resource, were significantly enriched at FDR < 0.05 (Figure 3), suggesting that dysregulation in any of these pathways may contribute to POAG development. The gene discussed is TGFB1; the disease is open-angle glaucoma.