MSH2 and diabetes mellitus: However, in the medullary compartment, diabetes decreased MSH2 expression by 1.38-fold (95% CI 1.16 to 1.6-fold, R2 = 56.86%, p = 0.0029, E = 41.75 in favor of Ha) at the 8-month timepoint, whereas, in 14-month-old rats, diabetes increased expression of MSH2 by 2.29-fold (95% CI 1.46 to 3.12-fold, R2 = 66.08%, p = 0.0077, E = 11.77 in favor of Ha) (Figure 2c).