On the other hand, at a 14-month timepoint, diabetes mellitus rats had increased expression levels of MSH2 in kidney by 2.01-fold (95% CI 1.15 to 2.87-fold, R2 = 52.79%, p = 0.0266, E = 2.659 in favor of Ha) (Figure 2a). The gene discussed is MSH2; the disease is diabetes mellitus.