The replication factor C (RFC) complex, which is an AAA+ATPase composed of one large subunit, known as RFC1, and four small subunits, RFC2/3/4/5, was first purified from the Hela cell extract of human cervical cancer and is essential for simian vacuolating virus 40 (SV40) DNA replication in vitro [1,2,3,4]. Here, RFC1 is linked to cervical cancer.